Publications

Research articles

• Toshima N, Schleyer M. 2024. IR76b-expressing neurons in Drosophila melanogaster are necessary for associative reward learning of an amino acid mixture. Biol Lett 20: 20230519. DOI: http://doi.org/10.1098/rsbl.2023.0519 

• Thane M, Paisios E, Stöter T, Krüger A-R, Gläss, Dahse A-K, Scholz N, Gerber B, Lehmann DJ, Schleyer M. 2023. High-resolution analysis of individual Drosophila melanogaster larvae uncovers individual variability in locomotion and its neurogenetic modulation. Open Biol 13: 220308. DOI: https://doi.org/10.1098/rsob.220308 

• Bormann A, Körner MB, Dahse A-K, Gläser MS, Irmer J, Lede V, Alenfelder J, Lehmann J, Hall DCN, Thane M, Schleyer M, Kostenis E, Schöneberg T, Bigl M, Langenhan T, Ljaschenko D, Scholz N. 2023. Intron retention of an adhesion GPCR generates single transmembrane-helix isoforms to enable 7TM-adhesion GPCR function. biorXiv. DOI: https://doi.org/10.1101/2023.01.11.521585

• Jürgensen A-M, Sakagiannis P, Schleyer M, Gerber B, Nawrot MP. 2023. Prediction error drives associative olfactory learning and conditioned behavior in a spiking model of Drosophila larva. iScience 21: 108640. DOI: https://doi.org/10.1016/j.isci.2023.108640

• Mancini N, Thoener J, Tafani E, Pauls D, Mayseless O, Strauch M, Eichler K, Champion A, Kobler O, Weber D, Sen E, Weiglein A, Hartenstein V, Thum AS, Rohwedder A, Schleyer M, Gerber B. 2023. Rewarding capacity of optogenetically activating a giant GABAergic central-brain interneuron in larval Drosophila. J Neurosci 43: 7393-7428. DOI: https://doi.org/10.1523/jneurosci.2310-22.2023 

• Thoener J, Weiglein A, Gerber B, Schleyer M. 2022. Optogenetically induced reward and 'frustration' memory in larval Drosophila. J Exp Biol 255: jeb244565. 

• Thoener J, König C, Weiglein A, Toshima N, Mancini N, Amin F, Schleyer M. 2021. Associative learning in larval and adult Drosophila is impaired by the dopamine-synthesis inhibitor 3-Iodo-L-tyrosine. Biol Open 10: bio058198.

• Weiglein A, Thoener J, Feldbruegge I, Warzog L, Mancini N, Schleyer M, Gerber B. 2021. Aversive teaching signals from individual dopamine neurons in larval Drosophila show qualitative differences in their temporal 'fingerprint'. J Comp Neurol 529:1553-1570.

• Schleyer M, Weiglein A, Thoener J, Strauch M, Hartenstein V, Kantar Weigelt M, Schuller S, Saumweber T, Eichler K, Rohwedder A, Merhof D, Zlatic M, Thum AS, Gerber B. 2020. Identification of dopaminergic neurons that can both establish associative memory and acutely terminate its behavioral expression. J Neurosci 40:5990-6006.

• Thane M, Viswanathan V, Meyer TC, Paisios E, Schleyer M. 2019. Modulations of microbehaviour by associative memory strength in Drosophila larvae. PloS One 14: e0224154.

• Mancini N, Hranova S, Weber J, Weiglein A, Schleyer M, Thum AS, Gerber B. 2019. Reversal learning in larval Drosophila. Learn Mem 26: 424-435.

• Weiglein A, Gerstner F, Mancini N, Schleyer M, Gerber B. 2019. One-trial learning in larval Drosophila. Learn Mem 26: 109-120.

• Toshima N, Kantar Weigelt M, Weiglein A, Boetzl FA, Gerber B. 2019. An amino-acid mixture can be both rewarding and punishing to larval Drosophila melanogaster. J Exp Biol 222: jeb209486.

• Saumweber T=, Rohwedder A=, Schleyer M=, Eichler K, Chen YC, Aso Y, Cardona A, Eschbach C, Kobler O, Voigt A, Durairaja A, Mancini N, Zlatic M, Truman JW, Thum AS, Gerber B. 2018. Functional architecture of reward learning in mushroom body extrinsic neurons of larval Drosophila. Nat Commun 9:1104.

• Damrau C, Toshima N, Tanimura T, Brembs B, Colomb J. 2018. Octopamine and Tyramine Contribute Separately to the Counter-Regulatory Response to Sugar Deficit in Drosophila. Front Syst Neurosci 11: 100.

• Almeida-Carvalho MJ, Berh D, Braun A, Chen Y-c, Eichler K, Eschbach C, Fritsch PMJ, Gerber B, Hoyer N, Jiangn X, Kleber J, Klämbt C, König C, Louis M, Michels B, Miroschnikow A, Mirth C, Miura D, Niewalda T, Otto N, Paisios E, Pankratz MJ, Petersen M, Ramsperger N, Risse B, Saumweber T, Schlegel P, Schleyer M, Soba P, Sprecher SG, Tanimura T, Thum AS, Toshima N, Truman JW, Yarali A, Zlatic M. 2017. The Ol1mpiad, or: Behavioural faculties of stage 1 Drosophila larvae. J Exp Biol 220:2452-2475.

• Michels B, Saumweber T, Biernacki R, Thum J, Glasgow RDV, Schleyer M, Chen YC, Eschbach C, Stocker RF, Toshima N, Tanimura T, Louis M, Arias-Gil G, Marescotti M, Benfenati F, Gerber B. 2017. Pavlovian conditioning of larval Drosophila: An illustrated, multilingual, hands-on manual for odor-taste associative learning in maggots. Front Behav Neurosci 11:45.

• Paisios E, Rjosk A, Pamir E, Schleyer M. 2017. Common microbehavioural 'footprint' of two distinct classes of conditioned aversion. Learn Mem 24:191-198.

• Kudow N, Miura D, Schleyer M, Toshima N, Gerber B, Tanimura T. 2017. Preference for and learning of amino acids in larval Drosophila. Biol Open 6:365-369.

• Croset V, Schleyer M, Arguello JR, Gerber B, Benton R. 2016. A molecular and neuronal basis for amino acid sensing in the Drosophila larva. Sci Rep 6:34871.

• Kleber J, Chen YC, Michels B, Saumweber T, Schleyer M, Kahne T, Buchner E, Gerber B. 2016. Synapsin is required to "boost" memory strength for highly salient events. Learn Mem 23:9-20.

• Schleyer M, Miura D, Tanimura T, Gerber B. 2015. Learning the specific quality of taste reinforcement in larval Drosophila. Elife 4: e04711.

• Schleyer M=, Reid SF=, Pamir E, Saumweber T, Paisios E, Davies A, Gerber B, Louis M. 2015. The impact of odor-reward memory on chemotaxis in larval Drosophila. Learn Mem 22:267-277.

• König C=, Schleyer M=, Leibiger J, El-Keredy A, Gerber B. 2014. Bitter-sweet processing in larval Drosophila. Chem Senses 39:489-505.

• Toshima N, Hara C, Scholz C-J, Tanimura T. 2014. Genetic variation in food choice behaviour of amino acid-deprived Drosophila. J Insect Physiol 69: 89-94.

• El-Keredy A=, Schleyer M=, König C, Ekim A, Gerber B. 2012. Behavioural analyses of quinine processing in choice, feeding and learning of larval Drosophila. PLoS One 7:e40525.

• Toshima N, Tanimura T. 2012. Taste preference for amino acids is dependent on internal nutritional state in Drosophila melanogaster. J Exp Biol 215: 2827-32.

• Schleyer M, Saumweber T, Nahrendorf W, Fischer B, von Alpen D, Pauls D, Thum A, Gerber B. 2011. A behavior-based circuit model of how outcome expectations organize learned behavior in larval Drosophila. Learn Mem 18:639-653.

= equally contributing first author

Reviews

• Toshima N, Schleyer M. 2019. Neuronal processing of amino acids in Drosophila: from taste sensing to behavioural regulation. Curr Op Insect Sci 36: 39-44.

• Schleyer M, Fendt M, Schuller S, Gerber B. 2018. Associative learning of stimuli paired and unpaired with reinforcement: Evaluating evidence from maggots, flies, bees and rats. Front Psychol 9: 1494.

• Diegelmann S, Klagges B, Michels B, Schleyer M, Gerber B. 2013. Maggot learning and Synapsin function. J Exp Biol 216:939-951.